All of the previous occasions that Manchester United and AC Milan have met in European competition have been in the Champions League
Manchester United will face seven-time Champions League winners AC Milan in the Europa League round of 16.
Second in Serie A, AC Milan have yet to win the competition, while United only triumphed in 2017.
Arsenal, finalist in 2019, face the Greek team Olympiakos, the knocked her out in the last 32 stage last year.
Tottenham will play against Croatian side Dinamo Zagreb, while Rangers have been drawn against Czech side Slavia Prague defeated Leicester City this week.
The last eight 16 games will be played on March 11th and 18th.
Former Manchester United striker Zlatan Ibrahimovic is set to return to Old Trafford in the second leg when the two teams meet for the 12th time in European competition – all previous meetings have been in the Champions League.
Rangers who a 9-5 overall victory via Royal Antwerp on Thursday to reach the last 16 for the second year in a row, will face Slavia Prague for the first time.
Tottenham’s opponent Dinamo Zagreb, who will host the first leg, have lost nine of their last ten games against English teams in European competition and won the other game in the 2015 Champions League group stage 2-1 against Arsenal.
The Gunners last had to accept two eliminations by the same club in 2014 – against Bayern Munich in the Champions League.
The clubs have until Monday to report problems related to travel to Uefa. A decision on confirmed venues will then be made.
Europa League round of 16
Ajax versus BSC Young Boys
Dynamo Kiev versus Villarreal
AS Roma versus Shakhtar Donetsk
Olympiacos v arsenal
Dinamo Zagreb v Tottenham
Manchester United v AC Milan
Slavia Prague v Rangers
Granada versus Molde
The teams drawn first play the second leg at home.