Avoid pain medication just before you get the COVID-19 vaccine, but they are “perfectly fine” according to experts.
Headache, fever, body aches, and chills.
While these are perfectly normal side effects of the COVID-19 vaccine – and a good sign that your immune system is working – they can be uncomfortable.
To minimize the discomfort, some Americans may turn to pain relievers such as acetaminophen or ibuprofen. Others fear that these drugs could make the vaccine less effective.
Studies on the subject are sparse and inconsistent, however the Centers for Disease Control and Prevention and the World Health Organization both recommend against the preventive use of pain relievers,However, allow them if symptoms develop afterward.
In a study published in the peer-reviewed Journal of VirologyResearchers found that nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce the production of antibodies and affect other aspects of the immune response to SARS-CoV-2, the virus that causes COVID-19.
The researchers said the results of the study opened the possibility that pain relievers like ibuprofen could alter the immune response to the COVID-19 vaccine.
Dr. Colleen Kelley, an associate professor of medicine at Emory University School of Medicine, who was not involved in the study, speculates that this could be caused by reducing the inflammation caused by the immune system.
“The immune system triggers a reaction through controlled inflammation. (Painkillers) can reduce the production of inflammatory mediators, ”she said. “So this is the potential mechanism for a decreased immune response to vaccinations when you take these drugs.”
According to Dr. Marian Michaels, a member of the COVID-19 Vaccine Advisory Board at the University of Pittsburgh Medical Center, studies have shown that the immune system reacts differently to the COVID-19 vaccine than it does to natural infections.
“We believe the (immune) response to the vaccine is actually a better response than the wild-type virus with COVID-19,” said Michaels, who is also a pediatric infectious disease doctor at UPMC Children’s Hospital in Pittsburgh. “For this reason, we recommend that anyone who has had an infection in the past continues to receive the vaccine.”
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On 2016 study from Duke University Examined the effectiveness of various vaccines in children and found that those who took pain medication before their regularly scheduled admissions had fewer antibodies than those who did not.
The few studies on pain medication and vaccines, however, aren’t robust enough to draw conclusions, experts say, as the children in the 2016 study who took pain medication and showed fewer antibodies still had a sufficient immune response to provide protection.
There is no data showing a decreased immune response when the drugs are taken after vaccination to treat side effects, Kelley added.
“It’s perfectly okay to take NSAIDs or Tylenol if you feel unwell after vaccination,” said Kelley. “The symptoms you are experiencing indicate that your immune system is working normally and that the immune response is continuing.”
Michaels notes that neither the Pfizer BioNTech nor the Moderna COVID-19 studies banned study participants from taking pain relievers, and that efficacy rates were still above 95%.
“Although I don’t have the exact number of people in the research study … I’m sure some of them took acetaminophen or ibuprofen because 70% had mild (vaccine side effects),” she said. “And yet there was still an immunological response.”
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